Plants are historically a supply of analgesic alkaloids, Whilst their pharmacological characterization is frequently confined. Among the these kinds of normal analgesic molecules, conolidine, located in the bark in the tropical flowering shrub Tabernaemontana divaricata
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Figuring out the mechanism of action (MOA) of novel or naturally developing compounds generally relies on assays tailor-made for unique goal proteins. Here we explore another approach based on pattern matching reaction profiles attained using cultured neuronal networks. Conolidine and cannabidio
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"The discovery of ACKR3 being a target of conolidine even further emphasises the role of the newly discovered receptor in modula